Efficient antibacterial/biofilm, anti-cancer and photocatalytic potential of titanium dioxide nanocatalysts green synthesised using Gloriosa superba rhizome extract

Background: Oral administration of biguanides (metformin) and sulfonylureas (gliclazide) are the most common approach of management of type 2 diabetes in humans. Among these diabetic patients, approximately 40–60% suffers from hypertension. Hence, the need of the day is application of polytherapy. A major challenge in polytherapy is the drug-drug interactions that may arise. Hence, this study is focused to develop a reverse phase high-performance liquid chromatography (RP-HPLC) method for concurrent estimation of diabetic drug metformin and hypertension drug valsartan using C18 column and find any possible pharmacokinetic interactions between the two drug combinations strategies, i.e., metformin-valsartan and gliclazide-valsartan in streptozotocin-induced diabetic rats. Result: The bioanalysis of drug-drug interaction pharmacokinetic result showed no significant difference in the tmax of single treatment of gliclazide and single treatment of metformin or upon co-administration with valsartan.
Conclusion: Our study has shown that polytherapy of valsartan, a drug administered for hypertension along with
hypoglycemic drugs metformin and gliclazide, can be advantageous and safe in patients suffering from both
diabetes and hypertension.