Development of an optical biosensor for the determination of choline in human biofluids

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Raja, Lavanya and Venkatesan, Srinivasadesikan and Ming-chang, Lin c and Vediappen, Padmini (2023) Development of an optical biosensor for the determination of choline in human biofluids. Journal of Molecular Structure, 1280. p. 135040. ISSN 0022-2860

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School: School of Applied Science and Humanities > Department of Chemistry

Department: School of Applied Science and Humanities > Department of Chemistry

Abstract

a b s t r a c t
An optical biosensor was developed for choline from a (E)-1-(4-aminophenyl)-3-(4-(dimethylamino) phenyl)prop–2-en-1-one (4ADP). The biosensor showed strong adsorption of choline in 4ADP with low detection limit of 21 nM was exhibited. This choline sensor 4ADP has been applied to the analysis of
choline in serum samples also the binding interaction has been confirmed by NMR titration, FTIR and DFT study. A set of experimental results indicate that the chalcone derivative selectively detects choline in the presence of other biomolecules with 1:1 binding stoichiometry through ICT mechanism.

Item Type:	Article
Subjects:	AC Rearch Cluster
Depositing User:	Unnamed user with email techsupport@mosys.org
Date Deposited:	06 Nov 2023 07:11
Last Modified:	06 Nov 2023 07:11
URI:	https://ir.vignan.ac.in/id/eprint/326

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