Stereoselective synthesis of (-)-Tetrahydropyrenophorol

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Ramanujan, V and Sadikha, Sk and Sai Pavan Kumar, N. S (2020) Stereoselective synthesis of (-)-Tetrahydropyrenophorol. J. Serb. Chem. Soc., 85 (9). p. 1129. ISSN 2683-3867

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School: School of Applied Science and Humanities > Department of Chemistry

Department: School of Applied Science and Humanities > Department of Chemistry

Official URL: https://doi.org/10.2298/JSC190823040R

Abstract

Abstract: Tetrahydropyrenophorol, an interesting macrodiolide was isolated from the plant Fagonia cretica. The total synthesis of (-)-1-tetrahydropyrenophorol was achieved in an elegant and linear manner from readily accessible racemic epoxide. The archetypal reactions include regioselective opening of epoxide,
Sharpless asymmetric dihydroxylation, and Mitsunobu cyclodimerization to construct the requisite 16-membered bis-lactone. The synthetic approach demonstrated here is very simple and can be used for the syntheses of related compounds an economic and highly stereoselective way

Item Type:	Article
Subjects:	AC Rearch Cluster
Depositing User:	Unnamed user with email techsupport@mosys.org
Date Deposited:	03 Nov 2023 05:37
Last Modified:	03 Nov 2023 05:37
URI:	https://ir.vignan.ac.in/id/eprint/270

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