Effect of Hydroxypropyl Methylcellulose and Microcrystalline Cellulose in Design and Optimization of Nebivolol Hydrochloride Immediate Release Tablets by Response Surface Methodology

The goal of the research is to design and optimize Nebivolol Hydrochloride immediate-release tablet using response surface methodology. Nebivolol Hydrochloride immediate-release tablets used in the treatment of heart attacks, myocardial infarction. Response surface methodology calculations for this optimization study were performed utilizing Minitab 17. Different formulations of immediate-release were prepared by applying 2 factors 3 levels full factorial design using Minitab 17, which gave 9 formulations by using the wet granulation method. Independent variables like the amount of hydroxypropyl methylcellulose (X1), and microcrystalline cellulose (X2) and dependent variables like the per cent drug release at 45 minutes (Y1), disintegration (Y2) were selected for optimization. The prepared batches of Nebivolol Hydrochloride immediate-release tablets were evaluated for the pre-compression and post-compression parameters like weight variation, thickness, hardness, and friability, disintegration, and in-vitro drug release studies. All the Physicochemical parameters were found satisfactory for prepared tablets. The optimized formulation F7 showed disintegrated in 83 sec, percentage dissolution release 97.85 at the end of 45th minute. The results shows that formulated immediate-release tablets of Nebivolol HCl were better to meet patient compliance with respect to effectiveness.